With three Premier League games in the nine days that follow this fixture, Liverpool boss Brendan Rodgers will be tempted to rest some of his star names for the visit of Young Boys.
Unfortunately for the Reds, it could be a similar story once again as they are only joint-second in their Europa League group.
“I would have loved to have kept them on the sidelines to give them a breather but obviously when you need them you need to put them on,” said Rodgers of Luis Suarez and Steven Gerrard when he introduced the pair in the cup tie against the Swans.
A victory here would ensure qualification if Udinese fail to win in Russia and that triumph is available at 1/2 (1.50) in this one.
Their Swiss opponents showed potential in a spirited display against Liverpool in the group opener and have grown into the competition since then, pulling off an unlikely double against Udinese.
Young Boys are a whopping 6/1 (7.00) to win away from home. The draw is available at 3/1 (4.00) .
Even if the home side do find a way of getting past Young Boys in the end, it seems likely that the visitors are at least capable of causing problems early on.
Liverpool have only led at half-time in two of their last 10 home games and, given that the line-up for this tie could be one that is thrown together, Rodgers’ team may struggle for fluency before the break.
As a result, the pick of the bets is to back Young Boys not to be behind at the interval – they are 4/6 (1.67) in the first-half double chance market .
In the second half it could be a different story and Suarez is 13/5 (3.60) to have the final say as last goalscorer.
Other goalscoring bets include Jonjo Shelvey, who scored two goals in the previous meeting between the sides, and Raul Bobadilla, who netted a hat-trick against Udinese.
Both men are available at 9/1 (10.00) to open the scoring.
But for the value bet remember that the first match between these sides finished 5-3 to Liverpool after 90 minutes. That makes the 4/1 (5.00) for over 4.5 goals this time around look very tempting indeed.
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Adam Bate is a professional freelance journalist who specialises in football and betting. He is editor of GhostGoal which can be found here – you can also follow Adam on 